منابع مشابه
Peripheral metabolic actions of leptin.
The ob gene product, leptin, is produced predominantly in adipose tissue. In ob/ob mice, a mutation in the ob gene prevents normal leptin production and results in a phenotype characterized by obesity and diabetes (Zhang et al. 1994). Daily injections of recombinant leptin to ob/ob mice inhibit food intake and reduce body weight and fat mass (Campfield et al. 1995; Halaas et al. 1995; Pelleymou...
متن کاملPeripheral actions of leptin and its involvement in disease.
The discovery of leptin is broadening our understanding of the mechanisms underlying neuroendocrine function. To date, most investigations have focused on the effects of leptin on food intake control and body weight homeostasis with attention primarily focused on the central effects of leptin. However, the almost ubiquitous distribution of leptin receptors in peripheral tissues provides a ferti...
متن کاملLeptin resistance and diet-induced obesity: central and peripheral actions of leptin.
Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions. The adipose-derived hormone leptin acts via a specific receptor in the brain to regulate energy balance and body weight, although this protei...
متن کاملThe glucoregulatory actions of leptin
BACKGROUND The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Despite significant efforts and relevance to diabetes, the mechanisms by which leptin acts to regulate blood glucose levels ar...
متن کاملMelanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin.
This study tested whether the melanocortin 4-receptor (MC4R) is essential for the chronic cardiovascular and metabolic actions of leptin. Twenty- to 22-week-old male wild-type (WT) C57BL/6J and obese MC4R (-/-) mice (N=5 to 6 per group) were implanted with radiotelemetric transmitters and catheters for measuring mean arterial pressure (MAP) and heart rate 24 hours per day and intravenous infusi...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 1998
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns19980064